Effects of dexmedetomidine or tramadol continuous rate infusions on the propofol requirements and cardiorespiratory variables in propofol-ketamine-midazolam anaesthetised cats

The aim of this study was to compare the effects midazolam-ketamine alone or in combination with dexmedetomidine tramadol a constant rate infusion (CRI) on minimum (MIR) propofol and cardiorespiratory function cats undergoing an ovariohysterectomy (OH). This prospective, randomised, blinded clinical study. Twenty-four healthy female mixed-breed were premedicated ketamine midazolam. Propofol used for induction maintenance anaesthesia (starting at 18 mg/kg/h). Cats assigned groups (n = 8) receive one following intravenous treatments: group (MKG; 0.6 mg/kg/h); midazolam-ketamine-dexmedetomidine [MKDG; mg/kg/h loading dose (LD) 1 mg/kg, CRI mg/kg/h)] midazolam-ketamine-tramadol [MKTG; (LD 2 mg/kg/h)]. During OH, adjusted based signs maintain adequate anaesthetic depth. Selected variables measured before (T0) after (T1) during six surgical time points (T2-T7). mean arterial pressure higher heart lower MKDG T1 (than MKG MKTG). ± SD MIR 17.4 3.2, 15.0 2.8 12.6 3.5 MKG, MKTG, MKDG, respectively. We conclude that, compared alone, reduced MRI by 13.8% 27.5%, respectively, without significant changes selected indicators.